Sphingosomes: Advancements and Emerging Applications in Advanced Drug Delivery Systems

Abstract

In a variety of different scientific fields, vesicular systems have proven to be very effective carrier systems. Sphingosomes are bilayered vesicles having a fully enclosed aqueous membrane lipid bilayer made primarily of sphingolipid, natural or synthetic. The instability, in vivo circulation duration, and cancer loading efficacy in cancer therapy are important limitations of the vesicle system (liposomes, niosomes) that are addressed by sphingosomes. The information was acquired by searching for Sphingosomes in the Scopus and Google Scholar databases. In clinical contexts, Chemotherapy, biological macromolecules, and diagnostics are delivered via sphingosomes. Due to their size and content, sphingosomes can take several forms. The report suggests that sphingosomes are a potential vesicular drug delivery system that may transport pharmaceutical substances for a variety of purposes.