Emerging Importance of Ceramides in Cardiovascular Disorders

Abstract

Sphingolipid consist of the sphingoid base backbone that are synthesized de novo from serine and fatty acyl-CoA. Then converted into more complex compound ceramides, phosphosphingolipid, glycosphingolipids and protein adduct. Sphingolipid are group of complex fats that help build and support cell membrane, structure and signaling. Ceramide a central molecule in sphingolipid metabolism, consist of sphingosine and fatty acid. Ceramide actively helps control various important cellular functions including apoptosis, proliferation, growth, death and response to stress. When ceramide levels are out of balance, it can contribute to diseases such as cancer, neurodegeneration, metabolic disorders, its significance in cellular homeostasis and human health recent years there's been growing interest in how ceramide contribute cardiovascular diseases. Focusing how ceramide related during various heart related condition such as hypertension, heart attack, atherosclerosis. We explore the role of ceramide in cardiovascular diseases discuss its potential as both diagnostic biomarker and therapeutic target. Ceramide production increases in response to high blood sugar level and inflammatory signals like tumor necrosis factor TNF-α.