Neurobehavioral and Antioxidant Activity of Crassula ovata Extract in Haloperidol-Induced Alterations in Albino Rats

Abstract

Aims:

This investigation was carried out to determine the behavioral and antioxidant effects of Crassula ovata leaf extract in albino rats exposed to haloperidol-induced alterations.

Study Design:

Randomized, controlled in vivo pharmacological study.

Methodology:

Thirty rats were divided into five groups (n=6). Behavioral deficits were produced using haloperidol (10 mg/kg, i.p.). A standard group received imipramine (25 mg/kg), while the test groups were treated with Crassula ovata extract at 200 mg/kg and 400 mg/kg. Behavioral responses were assessed using the Open Field Test (OFT) and Cage Climbing Test (CCT). Antioxidant status was evaluated by estimating superoxide dismutase (SOD) levels in brain homogenate.

Results:

Haloperidol produced a noticeable decline in locomotor activity, center-zone exploration, climbing duration, and SOD levels. Both doses of C. ovata ameliorated these changes, with the 400 mg/kg dose showing the strongest improvement. The extract enhanced center time, total distance travelled, and climbing activity. SOD activity increased significantly in the treated groups when compared with the haloperidol control.

Conclusion:

Crassula ovata improved behavioral responses and restored antioxidant enzyme activity in haloperidol-treated rats. The findings suggest that the extract possesses neuroprotective and antioxidant potential, with the 400 mg/kg dose showing the most pronounced effects.