Development and Evaluation of Licorice Root Extract-Based Cream for the Management of Hyperpigmentation

Abstract

Hyperpigmentation is a common dermatological condition caused by excess melanin production, which is frequently sparked by things like sun exposure, hormonal changes, and inflammation, or skin injury.  Conventional treatments, including hydroquinone and corticosteroids, are associated with adverse effects, leading to growing interest in safer, plant-based alternatives. Due to the presence of glabridin, a natural tyrosinase inhibitor, licorice root extract is well-known for its potent skin-lightening and antioxidant properties. The development and in-vitro evaluation of a topical cream containing licorice root extract for the treatment of hyperpigmentation were the primary objectives of this study. The formulation was assessed through preformulation studies, including solubility, pH, and partition coefficient analysis. Postformulation evaluations included organoleptic properties, pH, viscosity, spreadability, homogeneity, extrudability, and in vitro drug release. The final cream demonstrated excellent physicochemical stability, user acceptability, and a sustained drug release profile, indicating its potential as a natural, effective, and safe alternative for treating hyperpigmentation.