Neuroprotective Effects of Levetiracetam on Stress-Induced Somatic Changes in Experimental Animals.

Abstract

Objective: The present study aimed to evaluate the protective actions of levetiracetam (LVTM) in stress-induced experimental rats. Methods: In this study, 30 animals were randomly divided into five groups (n=6), and cold stress was induced. Treatment (Group-1 received normal saline, Group-2 served as Stress control, Group-3 treated with LVTM at 75 mg/kg concentration, Group-5 received LVTM at 150 mg/kg dose and finally the standard group served with Imipramine (IMPN) at the dose of 10 mg/kg) was administered to the animals 1 h prior to exposure to the stress condition. Results: For commencement of the results, different organs of the animals were weighed, namely the adrenal gland, Kidneys, Spleen, and Liver. After weighing the organs, the variation in weight was determined and it was found that LVTM significantly reduced the weight of the organs. For the preciseness of the impact, some biochemical [SOD (Superoxide Dismutase) and MDA(Malondialdehyde)] and hematological parameters were also assessed using blood samples from the animals, and it was observed that LVTM protected the animals against stress and remarkably reduced the levels of MDA (Malondialdehyde), triglycerides (TGs), Glucose, Blood Urea Nitrogen (BUN), and cholesterol. It also caused a considerable elevation in superoxide dismutase (SOD) activity. Conclusion: All of these interpretations have signalized that LVTM possesses the potential ability to counter stress and could be a good alternative to the medicines used in the treatment of stress.